Crossing over from the Negative Zone came the Annihilation Wave, a vast army commanded by Annihilus, bent on conquering the positive matter universe. Trying to hold off the invasion, the Nova Corps was destroyed, with Richard Rider remaining as the only surviving Nova. Rescued by Quasar and aided by Moondragon and Phyla-Vell, these cosmic champions must stand united against the Annihilation Wave!

This expansion brings a deadly cosmic conflict to Marvel United. Annihilus launches his forces against our universe and a powerful band of galactic Heroes must stand against his onslaught. A tough battle can get even harder with the addition of the Complication Challenge introduced by this expansion, as well as the relentless Harvester of Sorrow Location.